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With US Food and Drug Administration approval of targeted agents such as sunitinib and temsirolimus for the treatment of metastatic ccRCC and pRCC, respectively, correct subtype classification is highly desirable.
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Although the section only targets foreigners abroad, it doesn't require any suspicion of wrongdoing by or judicial approval of targets.
Since the approval of trastuzumab, targeted therapies are emerging as promising treatment options for the disease.
Increased understanding of endocrine resistance and the mechanisms of disease progression has led to development and subsequent approval of novel targeted treatments, resulting in the expansion of the therapeutic armamentarium to combat HR+ BC.
Generally speaking, these third-generation takeover statutes also known as "business combination" laws prohibit a would-be acquirer from engaging in a back-end merger with a target if the acquirer purchases a certain threshold percentage of the target's stock without first obtaining the approval of the target's board.
Yet the new rules make it almost impossible to pull off a triangular merger without the approval of the target firm's management.
A tender offer made directly to the stockholders to buy some or all of their shares for a specified price during a specified time period does not require the approval of the target company's management or board of directors.
Neighborhood activists have succeeded in overturning the approval of a Target shopping center, a 299-unit apartment building and the Millennium skyscraper project.
Schrage defended the company's use of targeted advertising but said "certain types of targeting will now require additional human review and approval".
Such losses can be particularly worrisome to younger workers because of what some see as an implied seal of approval accorded to target-date funds by the government and corporate 401(k) sponsors.
Few people made the connection at the time, but Herceptin's development-from the discovery of a surface marker on breast cancer cells in 1982 to the U.S. Food and Drug Administration's approval of a drug targeting that marker in September 1998-is a useful study of the financial risks, clinical problems, social ramifications, and rich rewards of personalized medicine.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com