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The marketing approval dates were obtained from public domains.
*For United States, Food and Drug Administration FDAapprovalval dates are used.
Table 1 describes the US advertising campaigns and Canadian approval dates for the three study drugs.
Self-reported pesticide use falling outside U.S. Environmental Protection Agency EPAapprovalval dates was not included.
Differences exist between the United States and Canada in terms of availability and approval dates for drugs.
Details of the approval dates, levels and quality of evidence, results of clinical effectiveness, annual costs and relevant references have been included as web appendices 1 4.
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IMB Application date 12.03.07 Approval date 27.04.07 Clinical trials approved committee Approval date 29.11.07 Data will be collected in duplicate on a case report form (CRF) at the time of recruitment by a trained researcher.
A second 6 month extension, for a total of 18 months from the original approval date, may be approved by the FSA State Committee.
Recruitment of study participants was performed according to protocol (ClinicalTrials.gov ID NCT01489839) approved by Forsyth Institutional Review Board ID #11-09 (Approval Date 8 August 2014) in Cambridge, MA, USA.
All studies were performed in accordance with the Guide for the Care and Use of Laboratory Animals, and all procedures were approved by The Jackson Laboratory Animal Care and Use Committee, comprehensive protocol #01026, approval date Nov. 29, 2007.
The whole blood sample for this study was collected under a protocol approved by the University of Louisville IRB (IRB tracking number 11.0659, approval date 1/30/2012).
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