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Use of PBPK should be appropriately weighed with the complexity of the question.
Moreover, the influence of single-organ versus multi-organ diseases needs to be appropriately weighed.
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America must not retreat from the age-old notion that 12 jurors can look a witness in the eye and, after hearing contradictory evidence, appropriately weigh his or her credibility.
No one other than a particular individual can appropriately weigh the potentially numerous and difficult to quantify considerations that would be involved in decisions of such a highly personal nature.
Although replication across different samples provides information on the genuineness of an initial association, meta-analysis appropriately weighs the effect and sample sizes across different replications samples.
We believe that for this population of mildly obese individuals, a full evaluation of their clinical characteristics is needed to appropriately weigh the benefit-to-risk ratio of the surgical intervention.
Finally, even if the difficulties in defining an outbreak and integrating and appropriately weighing the various sources of incoming surveillance data can be overcome, there still remains our third challenge: timely detection of outbreaks.
Ané and Sanderson (2005) use this MDL principle, based on information theory, to find a taxon-dependent penalty parameter to appropriately weigh the cost of substitutions versus that of recombination.
If you're unsure whether the item feels appropriately solid, weigh it, then compare its weight to similar items that you know to be ivory.
The transparency report acknowledges that the bank's expansion into investment banking was not planned in a sufficiently systematic manner, that incentives to generate revenues were not weighed appropriately against risks, and that this happened across business units, multiplying the bank's exposure.
Their analyses did not include any statistical adjustment for the dropouts that were not accounted for even through the most intensive outreach efforts, so the suggestion is that, had the deaths discovered through outreach been weighed appropriately, the true one-year mortality rate might have been higher still.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com