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These parameter estimates will provide effect sizes to appropriately power a larger study comparing the two formats.
This theory would be better tested with comparison of several smaller community sites along with obtaining an adequate sample size to appropriately power the study.
It is anticipated that the effect size observed in this trial will be useful to more appropriately power subsequent RCTs with the most effective dose of melatonin.
The future RCT will need to consider the minimally clinically important difference in the fatigue outcome in order to appropriately power the study.
Once established, a sample-size calculation can be performed prior to commencing a trial to ensure that investigators can correlate statistical significance to clinical significance and appropriately power their study.
The inherent biological noise, combined with sample error in these experiments, requires significant biological replication to appropriately power such experiments, and even when appropriately powered, false discovery rates still remain relatively high [ 39].
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While the categorical grading of injury severity may have been a reasonable solution to a clinical challenge identified in the middle of the 20th century, it is time to recognise the complexity of muscle injury, and to develop appropriately powered research projects to answer appropriate questions.
The number of well designed appropriately powered intervention studies continues to increase.
Although not statistically significant, it is acknowledged as a pilot project that the study may not have been appropriately powered.
An appropriately powered future trial is necessary to determine a potential role of amitriptyline in decreasing postoperative pain.
Despite these advancements, several issues remain to be resolved (Box 1), providing impetus for continuous optimization of CAR as well as appropriately powered, well-designed clinical studies.
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