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The task force also felt strongly that, in general, DMARD treatment should be started with MTX at appropriately high doses, possibly with the addition of GCs for the short term, before other measures are taken if the therapeutic goal is not reached within a maximum of 6 months.
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However, by averaging CRRT dose over time, studies in this area obfuscate the benefits of appropriately higher dose therapy early in the course of illness, potentially misguiding clinicians into blindly adopting a 'one-size-fits-all' approach and consequently prescribing inadequate doses in life-threatening emergencies.
High doses can cause fatal renal failure.
In high doses, aflatoxins can be deadly.
We know what happens at high doses.
High doses sometimes did more harm than good.
In high doses, it can cause brain damage in adults.
Frequent high doses of THC may overstimulate the endocannabinoid system.
Why was the patient on such high doses of vitamins?
These charts, until recently, indicated dangerously high doses for methadone.
It still reaches the liver, but not in high doses.
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