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This situation is sometimes referred to as extended labor, but it should more appropriately be considered labor cost escalation.
As noted earlier, sequences in this latter category could appropriately be considered to have statistically significant differences, but such differences may not be sufficient to constitute biological significance.
Patients who had a treatment-free interval of 0 5 months after first-line chemotherapy can appropriately be considered to have clinically defined platinum resistant disease.
This illustrates how expectations after baseline might more appropriately be considered an outcome rather than a nuisance variable that can be adjusted for in the analysis.
Thus, it appears that, while there is indeed an early (primary tumor stage) metastatic program under selection, it should appropriately be considered necessary but not sufficient for distant metastasis to occur.
However, it is also important to acknowledge that there are particular phase 1 oncology trials that may appropriately be considered to be purely investigative in intent (eg, study examining a single very low dose of a cytostatic agent attached to a novel isotope designed to image distribution of the delivered material).
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The Endocrine Society's Clinical Guidelines do not recommend population screening for vitamin D insufficiency in individuals not at risk, presumably cost implications having appropriately been considered here (www.endo-society.org).org
Also, the wall flexibility and the liquid-depth variation affects the response considerably and must be considered appropriately in design.
Apart from that, clinical-scientific findings and guidelines as well as patient needs must be considered appropriately and comprehensively.
They are essentially partially-restrained (PR) connections, and their presence adds yet another major source of nonlinearity that must be considered appropriately in nonlinear seismic response analysis.
Hence, different design strategies for building energy-saving should be considered appropriately according to different climate change characteristics in different climate zones.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com