Sentence examples for appropriately activated from inspiring English sources

This pathway was appropriately activated following induction of DNA damage with etoposide in ULTI cells cultured under both permissive and non-permissive conditions as determined by both autophosphorylation of the ataxia telangectasia mutated (ATM) kinase on serine 1981 and phosphorylation of H2AX on serine 319 (γH2AX) by ATM (Figure 2a).

This suggests that there are endogenous cellular mechanisms that can protect against damaging effects of hypoxia when appropriately activated.

When T-helper cells are appropriately activated, these lymphocytes will differentiate into effector T-cells that secrete distinct types of cytokines.

To test whether the 508 bp fragment of the DUSP6/ MKP- 3 promoter is appropriately activated in the context of a developing embryo, we placed this sequence into a reporter construct driving expression of destabilized EGFP (508ptkd2EGFP) [ 23].

One explanation for this apparent paradox is the well-documented ability of appropriately activated T cells to drive production of TNF-α from macrophages through a cell contact-dependent, antigen-independent mechanism [ 2].

IRF4 is another factor important for development of splenic CD4+ DCs (Tamura et al., 2005) but EBI2-deficient CD4+ DCs had normal levels of the IRF4 target Mmp12, suggesting that this transcription factor had been appropriately activated.

In order to build on and broaden the early clinical successes of genetically modified therapies, there are three key challenges that need to be addressed: appropriately activating T cells upon antigen recognition; counteracting the immunosuppressive effects of the tumour environment; and identifying new tumour-specific antigens (Kunert et al., 2013).

To start checking to make sure everything is working appropriately, activate the water and electricity to start experimenting with your handiwork.

At the same time however, signals generated by the ensuing negative energy balance appropriately activate neural mechanisms that can increase food intake.

Primary keratinocytes isolated from young hpm mice adhered well to ECM substrates but failed to spread, to proliferate and to survive in vitro, suggesting that the reduced β1 integrin levels are sufficient to promote adhesion but insufficient to appropriately activate signalling pathway(s) required for F-actin reorganisation, cell spreading and proliferation.

Furthermore, TgfB1+/- mammary epithelial cells fail to appropriately activate p53, indicating that the TGF-β ligand is essential for induction of rapid molecular responses to DNA damage that determine cell fate decisions.