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However, we have to take into consideration the small size of our control group, caused by the difficulty in identifying appropriated control subjects, especially for CF patients with significant short stature an pubertal delay.
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In this study we had difficulties finding young individuals to serve as appropriate control subjects.
However, it would probably be difficult to find appropriate control subjects to test this prediction.
We have compared the serum concentration of MIF in a large cohort of UK and Japanese gastric cancer patients, together with appropriate control subjects (age and gender matched).
To identify appropriate control subjects, we performed searches of the computerized medical record system at each PHCC to obtain lists of potential control patients according to ICD-9 codes for every underlying condition, and then we randomly selected 2 control subjects from the list of potential control patients with the appropriate conditions.
Comparison of DQA1 and DQB1 alleles in 60 children with common acute lymphoblastic leukaemia (c-ALL) and 78 newborn infant control subjects revealed that male but not female patients had a higher frequency of DQA1*0101/*0104 and DQB1*0501 than appropriate control subjects.
Starting from the GP's database, an appropriate control subject was matched to the case by age, sex, socio-economic level and type of vaccine.
For each incident case occurring during 8 years of follow-up, one appropriate control subject was selected at random from men who provided baseline blood samples at the time of diagnosis in the case patient.
However, immunologic studies have been limited by the availability of longitudinal samples from patients with IRIS and appropriate matched control subjects.
Studies (6, 10– 30) investigating adult patients with type 2 diabetes and appropriate healthy control subjects (weight-matched nondiabetic subjects) reporting plasma total GIP responses after oral glucose tolerance test (OGTT) or meal test were included.
For studies that include case-only collections, they would be encouraged to find appropriate sets of control subjects for genetic association analysis; if not available, those COPD study populations could be included in studies of COPD progression or CT subtypes.
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