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In patients who are not treated with insulin within 6 months of diagnosis, post-test probabilities of >25% would be appropriate to trigger genetic testing.
Although the absolute PSA levels considered appropriate to trigger ADT depend on multiple factors (PSA kinetics, tumour parameters and patient/clinician bias), a threshold of PSA level between 10 and 20 ng ml−1 is often accepted.
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As a response, reliability analysis was introduced to determine the appropriate time to trigger safety warnings according to the congestion intensity.
Malignant mammary cells could express matrix molecules that would create an appropriate microenvironment to trigger calcifications by hydroxyapatite formation [ 55].
The gold film absorbs the laser power and heats the solutions in the microfluidic channel filled with appropriate precursors to trigger the formation of 3D Ag@ZnO SERS substrates within the laser spot area.
To take this study further and understand whether the observed L-SR junctions could give rise to [Ca 2+] i transients of appropriate magnitude to trigger Ca 2+ release from RyR3 channels on the junctional SR, we developed a quantitative stochastic model of Ca 2+ dynamics in the junctional nanospaces.
Further research using modelling and simulations could examine an appropriate frequency of interim analyses, specifying situations when futility may or may not be appropriate, and which method(s) are appropriate, including whether to trigger the early looks on percentage of events or patients observed.
In contrast, RACK1 binds to the tyrosine kinases Src and Fyn to maintain these kinases in an inactive state until the appropriate signal occurs to trigger dissociation of the complex [ 29, 49, 55- 57, 61, 62] (see also Figure 5A).
However, the suggestion to offer universal testing has been advocated as many proband LS patients present with endometrial carcinoma as their sentinel tumor without appropriate family history to trigger IHC and/or MSI analysis testing.
An intelligent selection mechanism is developed based on an effectiveness index to trigger appropriate search methods.
A third is the absence of clinically relevant and validated cutoff values that help guide use of the biomarkers to trigger appropriate interventions and changes to patient management.
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CEO of Professional Science Editing for Scientists @ prosciediting.com