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Although better targeting of drugs to appropriate patient groups will let drug companies be more efficient in clinical trials, the approach could have a downside in post-marketing revenues ("Blockbuster Drugs Are So Last Century," July 3).
The benefit may be greater with targeting of the most appropriate patient groups.
However, defining the most appropriate patient groups for first-line gefitinib treatment raises questions that have yet to be answered.
Future studies should help to elucidate whether the benefit of aspirin outweighs risk in appropriate patient groups.
In some cases it means the cartoon is inappropriate and this can only be determined by field-testing cartoons with the appropriate patient groups.
[ 19, 20] The problem, therefore might be that treatments are not reaching appropriate patient groups, and their effect is diluted by the inclusion of heterogeneous patient populations.
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However, in the absence of data from a more appropriate patient group, this is best estimate available.
These analyses did not include two further factors which may be associated with decision appropriateness: patient group, and whether appropriate decisions involved the GPs performing an action (e.g. ordering a necessary test) or not performing an action (e.g. not prescribing unnecessary antibiotics).
The increasing number of causative "natural" alleles identified in human populations and inbred mouse strains will undoubtedly aid our understanding and prediction of genetic risk for T1D, as well as aid future clinical trials in selecting appropriate patient treatment groups based on their genetic profile (Bluestone et al. 2010; Polychronakos and Li 2011).
MAESTRAL may provide information that supports current guidelines and recommendations in terms of which treatments are the most appropriate for specific patient groups, in particular those with confirmed bacterial infections, as well as further evidence regarding the most appropriate study design for trials of antibiotics in outpatients with AECB/AECOPD.
But despite these findings, mindfulness isn't appropriate for some patient groups as Dr Christina Surawy, a clinical psychologist, warns: "MBCT isn't suitable for patients who are in the grip of a drug or alcohol dependency, as they won't be able to fully engage with the therapy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com