Clinical and laboratory criteria for notification according to the Ministry of Health, Singapore, are a positive culture of B. pseudomallei (which accounts for 96.5% of notified cases) or strongly positive serologic test results combined with appropriate clinical manifestations (9 ).
Substance (tǐ), literally body, is an entity in itself, while Function is its characteristic or appropriate activity or manifestation: a lamp is Substance, its light is function; an eye is Substance, seeing is its Function; water is Substance, waves are its Function.
While xanthogranulomatous osteomyelitis is benign, it can mimic malignant bone lesion in its imaging and clinical manifestations, and appropriate differentiation is crucial.
A careful history of dermatological manifestations and appropriate examination should be undertaken as well as ascertainment of contact history of those with characteristic HFMD signs.
Recognizing the appropriate combination of clinical manifestations, genetic testing and biochemical analyses could help improve NP-C diagnosis in this selected population.
Reinforcing his protestations about the OTO, Parsons described it as "an excellent training school for adepts, but hardly an appropriate Order for the manifestation of Thelema".
Veterinarians and horse owners should consider HeV infection in any horse exhibiting acute-onset febrile illness, regardless of clinical manifestations, and implement appropriate risk assessment and management strategies.
Education and training efforts should focus on key areas, such as recognizing the clinical manifestations of SARS, appropriate use of infection control practices and personal protective equipment, rationale and practical guidance for implementing isolation and quarantine, and appropriate use and interpretation of laboratory diagnostic tests.
Clinical outcome measures are to be defined based on evidence, taking into account the probability of detecting change given the expected natural progress of the organ-specific disease manifestations in an appropriate time-frame (potentially in contrast to the artificial time points used in clinical trials).
