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To provide an alternative basis for deriving an appropriate human exposure level from the Seychelles study, we conducted a benchmark analysis on these data.
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Both human cases resolved with appropriate antibiotics [ 26].
Insofar as dolphins are appropriate sentinels for human exposure, it is hypothesized that humans are exposed to these natural HOCs through seafood consumption.
Of all the animal models evaluated, juvenile swine are considered the most appropriate animal model for human exposure studies.
Finally, although the prenatal/neonatal rodent has proven an appropriate model for in utero human exposure to an endocrine disruptor, as illustrated in excellent studies of diethyl-stilbestrol (McLachlan et al. 1980, 2001; Newbold 2004; Yoshida et al. 1999), it is of little value for assessing postnatal development of infants exposed to isoflavones from soy formula.
For these substances, appropriate chronic animal and a controlled human exposure studies were available.
Oseltamivir use should be part of an integrated approach to reduce human exposure, together with the use and appropriate training of PPE.
The Committee noted that food additives may be consumed over a substantial proportion of lifetime and emphasised the need for studies in appropriate animal species that would reflect the conditions of human exposure.
Appropriate and timely collection of water lead level data would enable meaningful assessment of human exposure and also provide water treatment systems with insights regarding which exposure control strategies are most appropriate.
Its major determinants, such as exposure or dose effect relations, have to be studied in appropriate and often multiple animal studies to determine safe levels of human exposure.
Given the lack of appropriate meat inspection practices in majority of sub-Saharan African countries, human exposure to NTM through meat seems to be a viable route.
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