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Due to inherent safety issues, cholera toxin (CT), the model mucosal adjuvant used for many animal studies, is not appropriate for human use, and detoxified versions of CT and the closely related heat-labile enterotoxins (LTs) from Escherichia coli also have safety concerns for intranasal use in humans 6.
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In coastal temperate regions this technology may have significant potential to meet local energy demand, particularly in areas where the expansion of terrestrial biofuel production is limited due to high percentages of net primary productivity (NPP) already being appropriated for human use, such as the north Atlantic Coast of North America and Europe, and the western seaboard of South America.
They were never intended for human use.
Generally, it can be concluded that the studied polymers are well tolerated by the cells and appropriate for human chondrocytes growth, so they can be used in cartilage tissue engineering.
These constructs were used for production of recombinant proteins in E.coli or transfected into Xenopus or human (where appropriate, for human cDNAs) cells.
Management of ecosystem services refers to the management of 'areas of various scales in such a way that ecosystem services and biological resources are preserved, while appropriate human uses and options for livelihood are sustained' (Brussard et al. 1998 10).
The NCI's Drug Decision Network sponsored preclinical toxicity and pharmacokinetics evaluations of Pc 4 and developed a formulation appropriate for its use in humans.
These hollows can serve as natural shelters for animals, but have also been appropriated for some less scrupulous human uses: for instance, as a toilet, a prison, and a bar".
Animal studies are not appropriate for studying human infectivity as the animal hosts used are frequently immunodeficient and the infection pathway is frequently not representative of natural infection.
Although the Turing test was originally proposed as a test of a computer's ability to effectively mimic human behaviour, it was deemed appropriate for use on teenagers, given how modern teens mostly communicate via machines anyway.
Is it appropriate for the intended use?
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