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In conclusion, we have determined a profile of microsatellite markers appropriate for differential diagnosis of primary liver cancer.
In conclusion, we have determined a profile of molecular markers appropriate for differential diagnosis of primary liver cancer in the serum.
Since we are comparing four biological samples without replicates, a chi-square test based on normalized library size is most appropriate for differential expression analyses.
Consequently, these atypical smears were not appropriate for differential cell count analyses to define a potential mechanism of action of these compounds; we are currently performing detailed mechanistic studies with these compounds in vitro.
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A combination of the ROC curves for LRG1, IL-6 and CA19-9 yielded an AUC of 0.98 for the diagnosis of BTC vs PSC/IAC, supporting the concept that a combination of these markers may be an appropriate strategy for differential diagnosis in the clinic.
In the present study, the HSQC spectra were considered to be highly appropriate for the differential analysis, because they provide both H and C chemical shift information but yield much less complicated cross peak patterns than HMBC due to the restriction to only one-bond H C correlations.
Where appropriate, analyses which adjust for differential rates of measurement should be employed; these include marginal structural models for dynamic observation plans [ 19], interval censoring methods [ 18], and discrete time survival methods [ 20].
To determine the appropriate read depth criteria for differential gene expression, we examined the data for trends (see Methods for further details), and a 2X median read depth cutoff in one of the two samples being compared (i.e., ABA-treated vs. NaOH-treated) was chosen for examination of differential gene expression.
To call SFPs, a modified T-test [ 1], Robustified Projection Pursuit (RPP) [ 11] and SFP de-viation [ 5] have been developed to first estimate the normalized hybridization of a reference set of probes and then test with appropriate statistics or ratios for differential hybridization of specific probes across genotypes.
A large proportion of the genes dependent upon RosR for appropriate differential expression are of unknown function (30% of genes in response to H2O2 and 45% in response to PQ, Figure 7).
All analyses were conducted using the appropriate sample weights to correct for differential selection probabilities and to adjust for non-coverage and non-response in Stata version 12.1 (StataCorp, College Station, TX).
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