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An optimal design is reached by incorporating an analytical model and appropriate experimentation.
Indeed recent studies have demonstrated the expression of other type I MT-MMP family members (MMP-15, −16, and −24) in human atherosclerotic plaques, although their direct role in monocyte recruitment and plaque progression await the appropriate experimentation.
The power of this approach was immediately recognised, but worries about potential biohazards (Berg et al., 1974) suppressed the technology for a couple of years, before common sense and appropriate experimentation demonstrated its safety (Berg and Singer, 1995).
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We conform to generally accepted scientific principles, be based on a thorough knowledge of the scientific literature, other relevant sources of information, and adequate laboratory and, as appropriate, animal experimentation.
Opera is often the site of the greatest innovation in the visual arts of the theatre, attracting ambitious directors and designers who see its aesthetic (and budgets) as appropriate to spectacular experimentation.
Furthermore, in situations where the industrial environments impose constraints for an experimental validation such as recruitment of participants, the environment setting, and the reservation of needed equipment, it may be more appropriate to conduct experimentation in an academic environment.
Much of what we hear from society today is constant shame and guilt concerning gender-appropriate behavior, sexual experimentation, and the search for authentic and personal sexuality.
Much of what we hear from modern society is a constant source of shame and guilt concerning gender-appropriate behavior, sexual experimentation, and sexual expression.
The development of tissue-engineering strategies into clinical therapeutic protocols requires extensive, preclinical experimentation in appropriate animal models.
By experimentation, the appropriate range for the amount of waste PET was determined to be 4 6% by weight of the bitumen content.
Therefore, appropriate large-scale monitoring, experimentation and modelling are needed to determine the impact on the landscape from GMP trait characteristics [44].
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