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Heberlig acknowledged that fears of a bomb attack were ultimately misplaced but said the defendants responded with an appropriate escalation of force given what they suspected was happening.
As a result, periodic review together with timely adjustments and appropriate escalation of antihyperglycemic regimens to achieve target levels is imperative to meet therapeutic goals.
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Rapid risk stratification by identifying patients with acute massive and acute submassive PE is essential in determining appropriate treatment escalation beyond anticoagulation.
The tool is designed to identify patient deterioration and to trigger appropriate clinical escalations.
Nevertheless, we advocate in favour of appropriate de-escalation strategies that should be considered when culture results are available.
Inappropriate use of antibiotics with VRE activity may perpetuate resistance; therefore appropriate de-escalation is critical [ 6].
Our study did not address the issue of prescribing antimicrobials before cultures are drawn as the Surviving Sepsis guidelines [ 12] advocate for the initiation of broad-spectrum antibiotics followed by appropriate de-escalation.
Finalized cultures growing VSE may warrant appropriate antibiotic de-escalation, which is a critical stewardship issue.
This pilot study evaluated the role of dose escalation and appropriate target volume margin.
Patients were eligible if they met all following criteria: a) they had a diagnosis of hypertension, b) they had inadequate blood pressure control despite the use of antihypertensive medication and c) treatment escalation seemed appropriate.
The need to accurately diagnose VAP so that appropriate discontinuation or de-escalation of antimicrobial therapy can be initiated (to reduce the antimicrobial pressure) is evidently essential.
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