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Without an appropriate disease model, the understanding of the pathophysiology of intervertebral disc degeneration and inflammation is limited.
Fresh insights into the mechanics of diverse MET aberrations (amplifications and mutations) have allowed trial enrichment for appropriate patients in appropriate disease settings.
Neural stem (NS) cells are a limitless resource, and thus superior to primary neurons for drug discovery provided they exhibit appropriate disease phenotypes.
A lack of validated measures of outcome and uncertainty regarding the appropriate disease states in which to test these agents have led to difficulty in trial design.
Lumbar epidural steroid injection (LESI) is a valuable therapeutic option when administered to the appropriate patient, for the appropriate disease process, at the appropriate time.
However, during pastoralist focus groups, participants from all three tribes emphasized the importance of education on livestock health topics including identifying clinical signs of disease and understanding appropriate disease treatment and prevention.
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The most appropriate disease-specific scale is the Quality of Life Scale (Heinrichs et al., 1984) since it takes patients' cognitive deficits into account and because it allows to subtly measuring the patients' subjective feeling during a hetero-evaluation.
These genetic drivers of ASM can be identified in easy accessible tissue, which can then be followed up in the most appropriate disease-related tissue to examine for any surrounding CpG modulation.
It is reported to be the most appropriate disease-specific instrument for CAD [ 13].
One generic and appropriate disease-specific PROMs were selected to assess health status.
The major focus of FRDA iPSC differentiation research is currently focused on generating appropriate disease-relevant cell types.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com