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Appropriate carrier scaffolds for delivery of cells and drugs play a crucial role in tissue engineering and regenerative medicine.
This study suggests that local application of simvastatin, combined with an appropriate carrier, can promote new bone formation.
A local delivery system with sustained and efficient release of therapeutic agents from an appropriate carrier is desirable for orthopedic applications.
In terms of an appropriate carrier material, collagen scaffolds with homogeneous pore size of 65 μm were optimal for cell seeding and cultivating.
Several drugs including paclitaxel (PTX) which are used for cancer treatment are hydrophobic, exhibit poor aqueous solubility and need to be delivered using an appropriate carrier.
The hMSC survival and yield upon injection of compromised IVD could be improved by the use of an appropriate carrier and/or by predifferentiation of hMSCs before injection.
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Owing to their extreme hydrophobicity and low density, are considered as appropriate carriers for designing sustained release drug delivery systems.
Since free ODNs enter cells relatively poorly, appropriate carriers, often composed of polymers and cationic lipids, have been developed.
In this review, various microfluidic platforms for drug and gene carrier fabrication are reviewed to provide guidelines for designing appropriate carriers.
Achieving this goal requires general and flexible approaches allowing the construction of appropriate carriers and the elucidation of the key rules governing their capacity to supramolecularly interact with nucleic acids and mediate its active transport/delivery through biological membranes.
One of the challenges towards the clinical use of these biomacromolecules lies in the selection of appropriate carriers to protect, deliver and release them in vivo to maximize their pharmacological effects.
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