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And what's particularly striking in the case of the last three winners is how long they wrote in relative obscurity before receiving anything approaching widespread recognition, praise and, of course, financial security.
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Regardless of the approach, widespread use of IGRAs in serial testing is hampered by lack of evidence on several key questions (as reviewed elsewhere [10], [11]): a) What is the within-person reproducibility of T cell responses over time (in other words, what amount of variation is expected when IGRAs are repeated)?
Firstly, it was thought of as a recreational drug; then potential medicinal benefits emerged and later as the widespread (approaching pleiotropic) actions were identified it started to appear as if their actions were too widespread to biomedical and pharmaceutical utility.
A series of ticket-related scandals plagued the organizing committee as the Games approached, resulting in widespread public anger.
Passive approaches are widespread, and introduce no risk of instability.
The government's approach attracted widespread criticism from anti-apartheid campaigners led by the Anglican bishop Trevor Huddleston.
The "unilateral approach" is widespread in surgery for spinal degenerative pathologies.
If such an approach became widespread, border routers could be reconfigured to refuse outbound DNS requests except when received from authorized DNS servers.
As with every new approach, the widespread success of these techniques will depend on the general adoption of adequate diagnostic solutions and improvements in the technical parameters of these new regimens.
Recently, hybrid optimization techniques which combine different approaches receive widespread concerns.
Such indirect approach is widespread and allows comparison of practical characteristics of different membranes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com