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It is to be expected that comparative approaches will tend to underestimate the components of any given complex, since the approach is dependent upon the starting dataset.
The reduced sensitivity obviously means NMR-based approaches will tend to miss many low abundance serum metabolites (i.e. inflammatory or oxidation-status markers) of clinical interest.
For example, in Figure 1, sequence-based approaches will tend to assign z to the homologous family, { w, x, y }, because genes w and z share a homologous domain.
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A random split approach will tend to give optimistic results of model validation because the two datasets will be very similar.
However, this approach will tend to overestimate the percentage of uniques because not all individuals in the FSA will be unique.
This means that the FC approach will tend to give lower estimates for productivity gains for health care interventions for low-paid workers.
This selection approach will tend to favor genes with larger absolute expression levels, and a diverse range of expression values across the samples.
The denser the object, the more effective this approach will be.This will tend to work on stubborn spots, not an entire windshield.
The advantage of this approach is that it will tend toward producing more conservative outcomes (i.e., effect sizes) than the standard approach which assumes that unknown/unmeasured confounding is minimal.
Breyer's pragmatic approach to the law "will tend to make the law more sensible"; according to Cass Sunstein, Breyer's "attack on originalism is powerful and convincing".
Before a game, players will tend to approach the backstop and, in Boras's telling, thank him for the work he does on their behalf.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com