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However, Edwards (1989b) has shown that these initial theoretical approaches were too simplistic.
Second, the surgical approaches were too heterogeneous and often poorly described to perform subgroup analyses.
While early GWA genotyping approaches were too coarse to localize the causative polymorphism, fine mapping by the ImmunoChip across a large case control T1D cohort demonstrated that the most disease-associated variants, represented by rs2882971, lie within Treg cell-specific enhancers that are epigenetically conserved and lineage-specific in both human and mouse (Onengut-Gumuscu et al., 2015).
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Centralized approaches are too computationally intensive for real-time response.
Also the stagnation temperatures of more efficient approaches are too high for low-cost polymeric materials.
But there is a widely held perception that these approaches are too expensive.
Oliver Stone has defended his latest film, Alexander, saying its themes and approaches are too complex for Hollywood tastes.
Some of these approaches are too new to assess, but the general strategy appears to be bearing fruit.
As the concepts and the techniques in these two approaches are too different from each other, there have been no attempts to unify these approaches.
Genetic Algorithm (GA) has been one of the most popular methods for many challenging optimization problems when exact approaches are too computationally expensive.
These approaches are too passive.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com