Since the same target region may be scored more than once using this approach, we removed any duplicate regions from the results before the comparison.
In the proposed approach, we remove the "random" component by testing the statistics of the eigenvalues of the correlation matrix against a "null hypothesis" — a truly random correlation matrix obtained from mutually uncorrelated expression data series.
To determine whether the binding to the Rap1 C terminus is required for the function of the BAT domain we took two approaches: first, we removed the C terminus of Rap1, and second, we created a fusion protein with a shorter version of the BAT domain that lacks the RBM region.
In order to analyze the specific roles of these dynamic classes in the organization of the protein network, we undertook an in silico loss-of-function approach where we remove the desired set of proteins from the network and observe where the connectivity has been perturbed in the network (see Methods).
The value of this approach is also that we removed the confounding effect of doctor-patient miscommunication.
Following a straight approach, we can remove one measured flux at a time and perform the flux estimation to determine if the removed measurement was causing the low possibility.
In our approach, unlike [ 36], we remove duplicates from each generation to maintain the diversity of the population.
In addition, in order to test the impact of each single-model QA method on the performance of the consensus approach, we tested how removing each QA method may change the average Z-score of top one model selected by the consensus ranking of the remaining 13 QA methods.
While many previous approaches have removed these probes en masse [ 36, 46], we argue that they could remain for subsequent analysis.
The roadway and approaches were removed in preparation for the demolition.
