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Using structure- and property-based approaches, we designed 48 with improved cell potency (PC9 H3K4Me3 EC50 = 0.34 μM).
Exploiting the immunoinformatics approaches, we designed a potential vaccine by using the consensus epitopic sequence of 388 VSG proteins of T. brucei and performed in silico cloning of multiepitopic antigenic DNA sequence in pBI-CMV1 vector.
To combine the most favorable attributes of these two approaches, we designed and built an OKR apparatus in which a projector and laptop computer are mounted on a motorized rotating stage suspended 2 meters above the floor, with the optical axis of the projector coincident with both the axis of rotation of the stage and the axis of a white cylindrical test chamber at floor level (Figure 1A).
Taking advantage of the above embedding and the LSH-based spatial indexing approaches, we designed an efficient approximate compound structure similarity search algorithm.
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In this approach, we designed a sequential cyclization pathway for the formation of quinolizidine ring.
Based on a molecular modelling approach we designed and synthesized novel C15-substituted estrone derivatives.
In our research we took an alternative approach: we designed image-rich numeracy problems as alternatives for word problems.
Using a structure-guided approach, we designed an O13 mutant with further enhanced specificity for H-trisaccharide.
Using this approach, we designed Y-shaped, closed Y-shaped, H-shaped, and hexagonal structures with oligonucleotides.
To test the multiobjective approach, we designed a two-level Multiobjective Optimization algorithm for discovering Driving Strategies (MODS).
As the first step in such a design approach, we designed a new 2 1 multiplexer (MUX) cell, which is a key component in switches.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com