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Integrating genomic and biochemical approaches, we demonstrate that these sites of increased accessibility are associated with well-positioned nucleosomes marked by distinct histone modifications.
For each of these approaches we demonstrate how elements from various layers in the communication stack are developed using the molecular computing mechanisms.
By using parabiotic and chimeric mice, as well as adoptive transfer approaches, we demonstrate that training of the monocyte/macrophage lineage via BCG-induced HSC reprogramming is sustainable in vivo.
In summary, using a combination of several experimental and theoretical approaches we demonstrate that the inclusion of explicit solvent effects enhance QM/COSMO scoring to produce a reliable structure activity relationship with physical insights.
By comparing our approach to experimental measurements as well as alternative theoretical approaches, we demonstrate that it provides useful osmotic pressure results for polyelectrolyte systems composed of sodium poly styrene-sulfonate) without and with added salt over the whole range of monomer concentrations.
Using integrated multi-omics and imaging approaches, we demonstrate that the gut microbiota features oscillating biogeographical localization and metabolome patterns that determine the rhythmic exposure of the intestinal epithelium to different bacterial species and their metabolites over the course of a day.
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Using these approaches, we demonstrated that St14 was detected in PSCs, but not in MEFs.
Modifying CGCaP preparation approaches, we demonstrated scaffold variants of increasing mineral content (40 vs. 80 wt% CaP).
In a recent study, using pharmacological and genetic approaches, we demonstrated that histamine plays a critical role in malaria pathogenesis in mice [28].
Using multiple in vivo approaches, we demonstrated that endothelial Rac1 is not essential for tumor growth or tumor angiogenesis in adult wild-type mice, but that these processes become Rac1-dependent in the absence of β3-integrin.
By a combination of fluorescent confocal and electron microscopy, flow cytometry, electrophysiology, pharmacology, and genetic knock-down approaches, we demonstrated that these ion channels control cellular swelling and vacuolization of rat T9 glioma cells.
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CEO of Professional Science Editing for Scientists @ prosciediting.com