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We used the spatial uncertainty of the initial DSM approaches to stratify the study area and thereby to identify potential sampling areas of high uncertainties.
No consensus treatment regime exists beyond surgery for malignant peripheral nerve sheath tumours (MPNST), and the purpose of the present study was to find new approaches to stratify patients with good and poor prognosis and to better guide therapeutic intervention for this aggressive soft tissue cancer.
The challenge is to devise prospective diagnostic approaches to stratify women for appropriate adjuvant management, including identification of those women who require no adjuvant hormonal or chemotherapy.
This insight may be particularly helpful to future studies involving large data sets with multiple classes of genomic information, for example the Cancer Genome Atlas (TCGA) or the International cancer Genome Consortium (ICGC) that are relying on ever higher-resolution next-generation sequencing approaches to stratify patients and identify disease-specific driver mutations.
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These studies show that mitochondrial dysfunction caused by defects in mitophagy can promote the Warburg effect and tumor progression, and suggest better approaches to stratifying TNBC for treatment.
Other clues are available to suggest approaches to stratifying risk in the ANA-positive population.
Kheirbek, M. A., Klemenhagen, K. C., Sahay, A. & Hen, R. Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders.
Based on a slope area analysis, and complementary to theories of channel pattern discrimination, constant stream power curves (with power-law exponent of − 0.4) provide a first-order approach to stratify river reaches in terms of glacial conditioning and expected planform morphologies.
[18F]FDG-PET/CT texture analysis seems to be a promising approach to stratify the patients with thyroid incidentaloma identified on PET scans, with respect to the risk of the diagnosis of a malignant thyroid nodule and thus, could refine the selection of the patients to be referred for cytology.
These inconsistencies likely reflect both inter- and intra-tumoral heterogeneity, and a new, complementary phenotype-based approach to stratify and prognosticate lung cancer should be considered.
We present a novel approach to stratify tumors based on molecular signatures of CIMP that are evaluated in a unified manner across different cancer types.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com