Sentence examples for approaches to interrogate from inspiring English sources

To understand how novel TF specificity evolves, we combined phylogenetic, biochemical, and biophysical approaches to interrogate how DNA recognition diversified in the steroid hormone receptor (SR) family.

The next big step will be to implement mathematical modeling approaches to interrogate the enormous amount of data being produced and extract useful answers (a "top-down" approach to biology and medicine).

Currently, his group is focused on three primary areas: small molecule approaches to interrogate how lipid modifications on proteins regulate metabolic signaling and disease; developing new evolutionary tools for the rapid creation of therapeutics; and creating new synthetic biology approaches to study and control cell signaling by RNAs and proteins.

Chávez uses these methodological approaches to interrogate how coalitions, radical activists, and immigrant and queer rights' groups function within the larger framework of immigration and queer rights debates as well as exploring the new theoretical concepts that emerge from this methodological approach.

Thus, systematic approaches to interrogate synergistic compound combinations and to link these to individual genetic lesions are required to move these combinations into clinical trials more rapidly.

Software tools to find these variants deploy different mathematical approaches to interrogate the genome sequences of tumour/germline paired samples.

One of the most productive approaches to interrogating the antigenic diversity of HIV viruses for conserved shapes that may be immunologically targeted is to isolate monoclonal antibodies from HIV-infected human subjects and study their specificities, specifically their ability to neutralize in vitro infection by diverse HIV viruses.

We also explore the possible future developments of ChIP-based approaches to interrogating long-range chromatin interactions and their impact on the mechanisms regulating gene expression.

Constraint-based modeling is an approach to interrogate capabilities of reconstructed networks by constraining possible cellular behavior through the imposition of physicochemical laws.

These rationally-designed partial agonists provide an approach to interrogate whether control of maximal activity can provide glycemic control with reduced hypoglycemic risk.

Using our keratinocyte differentiation system, we employ a multi-dimensional genomics approach to interrogate the contributions of inductive morphogens retinoic acid and bone morphogenetic protein 4 (BMP4) and the epidermal master regulator p63 (encoded by TP63)4,5 during surface ectoderm commitment.