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The aim of this document is to explain this statement and review new approaches to decipher the existing but complex link between scaffold architecture and in vivo response.
Considering these differences, further approaches to decipher the role of developmental signaling pathways in human lung development are required, using, e.g., human histological samples [50] or human induced pluripotent stem (iPS) cells [48].
As these approaches yield massive datasets, systems level analyses have drawn upon other fields such as engineering and mathematics, adapting computational and statistical approaches to decipher relationships between molecules.
Therefore, it becomes critical to develop new approaches to decipher the expression of miRNAs.
There are many approaches to decipher a genome-wide DNA methylation profile, including methylated DNA immunoprecipitation-sequencing/chip (meDIP-seq/chip), bisulfite-sequencing (bis-seq) and some enzyme digestion based techniques.
We decided to employ both approaches to decipher the human islet clockwork.
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The utility of metagenomics approaches to deciphering such novel functionality in these systems is also highlighted.
Biology thrives on complexity, and yet our approaches to deciphering complex biological systems have been simple, observational, reductionist, and qualitative.
Combining powerful detection methods, fluorescent proteins and image analysis algorithms, it will be possible to offer novel approaches to deciphering interactions between mRNAs, their trans-acting factors, cytoskeletal structures and molecular motors in vivo.
First, we emphasize that the genome factor hypothesis and the gene pleiotropy hypothesis represent two distinct approaches to deciphering the functional constraint of protein sequence evolution.
The research presented here demonstrates the importance of multi-dimensional approaches to deciphering density stress responses and highlights the need for further investigations into the impact of combinatorial stresses on plant development and yield.
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