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Although there are high expectations for these complex approaches, they require careful evaluation.
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We have analyzed the requirement especially in consideration of the current situations facing the biologists working with large-scale omics data with systems biology approaches, where they require a comprehensive understanding of cellular workings.
The changes and requirements are less prescriptive compared to the SUPAC IR/MR approach, although they require a detailed and documented understanding of the formulation and process with a focus on continuous learning and improvement.
Although the inevitable conclusion from both of these studies remains that the approaches they outline require standardisation and testing in adequately powered randomised controlled clinical trials, they provide enough promise to warrant doing so.
The main inconvenient of such approaches is that they require the help of Laban concepts experts, in order to annotate the corpuses and come to a ground truth.
The only potential drawback to these approaches is that they require a search algorithm to determine the optimal RF and it may be difficult to avoid local optima.
While these approaches are useful, they require data on the burden of disease in the target population.
One drawback of these latter approaches is that they require carefully annotated, genome-scale metabolic network, of which is only available for a handful number of species.
Another limitation of these approaches is that they require repetition of the experiment in case the optimization parameters are to be modified or there is a change in the objective function.
The main restriction of this approach is that they require an approximation of the comportment in the thickness.
Although PCR assays are more accurate, specific, and faster than the microbiological approach [ 18- 20], they require precision equipments which are beyond the capacity of most diagnostic sites to purchase, maintain and operate, and the complexity of the assay procedures obviates the possibility of point-of-care use.
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