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Moreover, numerous approaches testing combinations of BRAF/MEK inhibitors or BRAF/PI3K inhibitors are underway [ 48].
However, for GSA approaches, testing hypotheses other than the equality of the mean expression vectors remains underexplored.
Accordingly, in approaches testing for statistically significant evolution of phenotype by natural selection, gross phenotypic difference has historically been precisely the signal assessed (Lande 1976, 1977; Lande and Arnold, 1983; Lynch 1990; Turelli et al. 1988; Charlesworth 1984).
Biologically, almost all studies suggest that once an optimal response is achieved, the residual Ph+ cells may not be completely BCR-ABL1 addicted, and are resistant to TKI inhibition, so that it may be necessary to consider other approaches testing other drugs in trials where toxicity and safety may prevail.
They use nutritional, biochemical and genetic approaches, testing the impact of dietary oxidants and antioxidants on survival of developing animals, measuring the accumulation of biochemical markers of oxidative stress and response, and quantifying the expression levels of genes involved in the oxidative stress response.
Similar(55)
The Duan [29] approach outperforms all the other approaches tested.
The baseline methods underperformed all other transfer learning approaches tested.
Other transfer learning approaches tested include an approach from Pan [87], Blitzer [5], and Gopalan [43].
It combines all of those approaches, tests out different "weighting" systems, and goes with the combination that's most effective.
Various approaches tested using synthetic catalogs are listed in Table 1 for ease of reference.
The other transfer learning approaches tested include the approach by Bruzzone [11], Schweikert [101], Duan [29], and Chattopadhyay [14].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com