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This review summarises the approaches, progress and challenges in the design of small-molecule inhibitors as antimalarial drugs targeting the inhibition of various malarial proteases.
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It is unclear whether high-throughput experiments or high-performance computers or very clever algorithms will dominate eventually, as the development of all three approaches progresses very fast.
In spite of the new deal, and fragile states' persistent calls for a fresh approach, progress on the ground has been sluggish.
Through a combined approach, progress has been made towards providing detailed structures of highly complex and very large viruses, and towards imaging the dynamic structural changes performed by viruses at key stages in their life cycles.
Basically, this approach progresses in two parts.
Despite these concerns and unanswered questions, the immunisation approach progressed to human clinical trials (see the 'Human clinical trials' section below).
Yet manual approaches for progress tracking lack the required accuracy for integration with other construction interfaces.
How these gene-therapy approaches will progress further will be an issue for future pre-clinical animal studies.
With these approaches substantial progress has been made in assessing receptor expression and determining ligand specificities, thus setting the stage for investigations on the mechanisms of OR signal transduction, which have yet to be resolved unequivocally [13], [14], [15].
These studies routinely employ approaches like progress curve analysis based on curve fitting to compare initial rates, or natural and recombinant cleavage site mutants to detail mechanistic features.
We begin with a general overview of epilepsy genetics, followed by a more detailed discussion of approaches and progress in gene identification in the complex epilepsies.
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CEO of Professional Science Editing for Scientists @ prosciediting.com