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Inferring the distribution of fitness effects by likelihood approaches often requires a well-defined demographic scenario (Keightley and Eyre-Walker 2007; Boyko et al. 2008; Eyre-Walker and Keightley 2009).
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However, these approaches often require computationally ML searches, which is unattractive in online process.
However, it is NP-complete and approximate approaches often require requires extensive exploration and evaluation.
Kinetic modeling approaches often require long scan times and are often followed by complex fitting routines to extract the kinetic parameters from the time activity curves (TACs).
Because personalized therapy approaches often require collecting and maintaining tissue and blood samples for interrogation in the laboratory, participants also learn the logistics of biospecimen banking and how to ensure specimens retain their research value for years to come.
Build trust: Outcomes-oriented approaches often require collaboration between people unused to working together.
However, these approaches often require repeated administration or control release systems [ 11].
Conventional approaches often require multiple genetic tests before a molecular diagnosis is reached and each clinical genetic test is often very expensive.
In addition, mass spectrometry-based approaches often require considerable amounts of time and a high level of technical expertise to complete assays, operate instrumentation, and perform data analysis.
An example of a pre-synthesized chromophore catalyst assembly is shown in Fig. 5, and this approach often requires multistep procedures with poor overall yields.
Processes and rates of ecosystem development can be reconstructed using lacustrine sedimentary sequences, but this approach often requires records that contain the start of primary succession.
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