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Three approaches of meta-analysis were eventually used for the selection of genes of interest.
It also outlines the spectrum of semantic heterogeneity and introduces the approach of meta-data implantation and stepwise evolution.
The main concern relates to the synthetic approach of meta-analysis that emphasizes summarizing evidence over the search for heterogeneity [ 79].
With notable exceptions such as the recent approach of meta-narrative analysis [ 15], critique of papers in current approaches to review tends to be limited to appraisal of the methodological specificities of the individual papers.
Second, using the alternative approach of meta-regression we found that age explained 6.3% of the heterogeneity across studies and had a significant association (p = 0.014) with the reported incidence of diarrhea.
While the latter approach of meta-genomics is (10 20×) more expensive and generates vast amounts of data with concommittant challenges in mapping and data-analysis, most epidemiological studies focus now on establishing 16S datasets and mostly derived from stool.
Here, we evaluate the performance of different approaches to meta-analysis in the presence of allelic heterogeneity.
The CAMARADES (Collaborative Approach to Meta Analysis and Review of Animal Data from Experimental Stroke) group have successfully applied such methodology to stroke models [ 43].
A hierarchical approach consisting of meta-heuristic algorithms such as a tabu search and a genetic algorithm was proposed to generate proper schedules.
Bipat et al [ 11] discussed a multivariate random-effects approach for meta-analysis of cancer staging.
48 The classical approach to meta-analysis of trials is to assume that the summary statistics have a normal likelihood, which however may not hold true when a trial is small.
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