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The morphology of the walls and their degree of match, quantified through various approaches, has proved to be an important parameter as regards both normal stress (evolution of the contact surfaces with increasing stress) and shear (evolution of the friction surfaces according to their "angularity").
Despite promising preclinical data, translation of CD40/154 blockade approaches has proved difficult due to the expression of CD154 on platelets, which causes risk of thromboembolic events.
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Despite almost three decades of intensive efforts, none of these approaches has proven to be ready for clinical application.
Generation of pneumocandin derivatives with more desirable pharmacological properties via medicinal chemistry approaches has proven difficult [ 16, 17].
Computational biology approaches have proved to be reliable tools for the selection of novel targets and therapeutic ligands.
The first two of these approaches have proved to be the most successful (Table 1 >).
For agents that cannot be cultured by standard techniques, these approaches have proved invaluable for identification and characterization studies.
Such approaches have proved advantageous in drug studies in other 'vulnerable patient' populations, such as paediatric patients 44.
Gene deletion approaches have proved particularly useful in dissecting the physiological role played by specific chemokines and chemokine receptors.
That approach has proved elusive.
The same approach has proved successful in treating tuberculosis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com