Exact(2)
Developments in optical approaches to measure activity have increased density and cell-count recordings2, but such approaches cannot reliably identify the precise timing of spikes of neuronal activity, and recordings are typically limited to structures near the brain's surface.
Furthermore, software fusion approaches cannot reliably compensate for the differences in respiration, peristalsis, and filling of bowel and bladder that frequently occur between images of thorax, abdomen and pelvis acquired at different times [ 6].
Similar(6)
Despite the advantage of straightforward determination of proteolytic epitopes, the single protease approach cannot reliably mimic the complexity of a whole degradome since concerted action of proteases might be crucial in the kinetics of antigen degradation.
Another disadvantage of our approach is that it cannot reliably measure trends at the very start of the observation period (since there are no previous risk scores for comparison).
Traditional morphological approaches cannot discriminate all the species reliably and habitus is generally very variable.
However, the identification of (small) deletions and insertions with comparable or shorter length than the standard deviation of paired-end insert sizes requires de novo assemblies, because such SVs cannot reliably be identified by mapping approaches.
The data emphasize the critical importance of including an in vivo gene expression filter in this type of approach, since clearly the directionality of Smad3 target gene regulation in vivo cannot reliably be extrapolated from in vitro results.
Traditional approaches that are based on theories of stationary signals cannot resolve nonstationarity-related issues and, thus, cannot reliably assess nonlinear interactions in physiological systems.
Related(1)
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