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The calculation is based on the electronegativity equalization method (EEM [22]), a powerful empirical approach which can provide atomic charges similar to those generated by various QM approaches, but using much lower computational resources.
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However, Oreopoulos et al. (2006) using the same approach, but using US Census data from 1960 , 1970 and 1980 report that an increase in parental education by one year decreases the probability of a child repeating a schooling year (or grade) by between two and seven percentage points.
Woolson, Ogonda, and O'Brien reported 12, 1.8, and 6%, respectively, of early complications in their series of total hip arthroplasty performed through mini-approach but using standard instrumentation [7, 8, 9].
Lu et al. [7] also reported a similar approach but using AceView as the reference database.
Then, the same experimental approach but using paclitaxel was performed.
Following the same methodological approach, but using data on PHC organizations in two regions, we derived another taxonomy that is very consistent with the policy synthesis.
To identify soluble compounds that bind to the PHD HD1 complex with increased LE, we adopted a fragment-based approach, but using protein-observed NMR spectroscopy as our primary screen.
A similar approach, but using line cross linkage mapping, has been used previously to narrow the number of candidate polymorphisms down to a single causative (Schneeberger et al. 2009; Mokry et al. 2011; Uchida et al. 2011; Austin et al. 2011; Abe et al. 2012; Lindner et al. 2012; Zhu et al. 2012a, b).
A randomised controlled trial conducted in New Zealand used a management strategy incorporating exhaled nitric oxide (NO) readings and achieved control that was at least as good as that obtained with a guideline-based approach but using a lower inhaled steroid dosage[ 59].
We would like to note, however, that our observations were based on a collection of cis-regulatory genes from independent studies, conducted in different laboratories using different approaches, but confirmed using an independent dataset with a larger sample size.
That is likely to be an underestimate, since the European Commission is keen that the system be widely adopted in Europe; and no big bank is eager to admit that, for want of expertise, it has to use the standardised approach.But using internal ratings is fraught with problems.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com