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Finally, we have not compared our approach with methods that rely on replicate genotypes.
SET is mainly based on a functional approach with methods to improve physical fitness [ 15, 16].
We extensively test our formulation in several demographic scenarios, compare our approach with methods based on ancestry deconvolution and use this method to analyze Masai samples from the HapMap 3 dataset.
To compare our IBD-based approach with methods based on ancestry deconvolution, we simulated the demographic scenario of Figure 7, where two populations split G s generations in the past, and G a generations in the past contribute a fraction of genomes to the creation of a group of admixed individuals, with probability m and, through a unique pulse of migration.
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Accordingly, the statistical validity and efficiency of the BMD is higher using the hybrid approach, compared with methods involving dichotomization of a continuous outcome (Crump 2002; West and Kodell 1999).
In literature, there are two approaches with method-level granularity: CLAN (Mayland et al. [1996]) and NICAD (Roy and Cordy [2008]) which is closely comparable to our own.
Although we did not extensively compare our approach with these methods, we performed a preliminary comparison with a well known Gene Set Enrichment Analysis (GSEA) method [ 49].
Moreover, the fusion of feature searching approach with watermarking methods has gained prominence in the current years.
To compare our approach with other methods, we use three-feature extraction strategies suggested in [29, 37, 38].
Such works are part of the recent trend to examine prospect-refuge theory mathematically or in a combined approach with survey methods and computational analysis.
Researchers should exercise caution when interpreting the γ statistic in studies examining diversification rate variation, and should supplement this approach with other methods aimed at detecting rate variation (e.g., [5], [8], [10]).
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