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Using this approach, we discovered that plasma membrane-bound respiratory syncytial virus G rapidly recycles from the membrane via clathrin-mediated endocytosis.
Using this approach, we discovered that the Nur77 ligand-binding domain (Nur77LBD) enriched unsaturated fatty acids (UFAs) in tissue lipid mixtures.
Through a structure-based drug design approach, we discovered a highly potent (IC50: 7 nM) irreversible BTK inhibitor compound 9 (CHMFL-BTK-01), which displayed a high selectivity profile in KINOMEscan (S score (35) = 0.00) among 468 kinases/mutants at the concentration of 1 μM.
Using this approach, we discovered that loss-of-function of TP53 can promote the development of resistance of castration in prostate cancer cells via both transiently potentiating androgen-independent cell growth and facilitating the occurrence of genome instability.
Using this approach, we discovered a large region (∼3 Mb) of unusually low divergence between Indica and Japonica near 10Mb on chromosome 5, extending through the centromere.
Using this approach, we discovered six novel and 39 candidate miRNAs, and delineated the expression pattern of 498 previously annotated miRNAs in normal primary HOSE cultures and epithelial ovarian cancer tissues.
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Using our approach we discover many classes of statistically significant shifted patterns for the root dataset.
Using whole-genome sequencing and genetic approaches, we discovered that deletions in a region including the transcriptional repressor (nagR) that regulates the expression of genes associated with catabolism of N-acetylglucosamine are the common basis for evolved glucose metabolism across populations.
Using both overexpression and knockdown approaches, we discovered that GRP78va selectively upregulates PERK signaling.
Using genomic approaches we discovered FMR4, a primate-specific noncoding RNA transcript (2.4 kb) that resides upstream and likely shares a bidirectional promoter with FMR1.
Using bioinformatics and molecular approaches, we discovered five different SUN-domain genes (here designated ZmSUN1- 5) in the maize genome.
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