The Reagan Administration used a cap-and-trade approach to phase out lead in gasoline.
The application of the solute drag approach to phase transformations is discussed.
Tracer experiments showed a reasonable approach to phase uniformity, and experiments with four systems gave reliable, consistent mass transfer coefficients.
This paper presents a novel approach to phase-interface transport based on pseudo-spectral sub-grid refinement of a level set function.
To accelerate development of these new reperfusion regimens, an integrated approach to phase II clinical trials that incorporates multiple efficacy variables, including angiography and noninvasive biomarkers of microvascular dysfunction, should be considered.
Upon invoking both volume and entropy continuity via the integral approach to phase equilibrium at second-order transitions, electric field effects on the glass transition are developed that parallel the Ehrenfest equations for the pressure dependence of Tg.
The relevance of this approach to phase I studies involving combinations of targeted drugs with radiation must be carefully considered.
Importantly, the availability of biomarkers and biomarker assays is critical to consider in planning the approach to phase 1 clinical trials [ 11].
The results of the review were used to create a library of currently available designs, and to develop a structured approach to phase II trial design outlining key points for consideration.
This review examines the evolution of phase I trials and draws upon several examples of strategies that have been successful as well as those that have not, and outlines a pragmatic approach to phase I trials as our understanding of the molecular biology of individual malignancies emerges.
