Sentence examples for approach to alignment from inspiring English sources
HMMSplicer's unbiased approach to alignment, combined with the sequence level power of RNA-Seq, has enormous potential for biological inquiry into alternative splicing.
The conservative approach to alignment that we use with mitochondrial protein sequence is to remove all gaps and flanking sites on either side of the gap back to a constant site.
The first probabilistic approach to alignment of tandem duplications was introduced by Hickey and Blanchette [ 15], who developed a new probabilistic model by combining PHMMs with tree adjoining grammars.
Recently, we proposed an alternative approach to alignment-free sequence comparison.
The Universal Sequence Map (USM) procedure expands the Chaos Game Representation (CGR) approach to "alignment-free" analysis of sequences of any alphabet.
We used two different approaches to alignment (direct optimization and homology-extension alignment) and tree building (parsimony and ML), to illustrate the effect of very different data treatments.
Furthermore, using automated approaches to alignment avoids the problems of the investigator's bias and the lack of reproducibility that may be related to manual alignments [ 32].
Other approaches to alignment graph partitioning may also lead to improvements in the accuracy of MSARC, for example a better method of pairing residues for multilevel coarsening than the currently used naive consecutive neighbors merging.
The structure-based sequence alignments are correlated with the PCAIN-based anchored alignments to estimate the efficacy of the PCAIN approach to sequence alignment (Figure 4C).
The optimization method that we introduced herein is inspired by the so-called progressive approach to multiple alignment introduced in the 1980s for the classical multiple-alignment problem [ 17].
An alternative, more statistically justified approach to assess alignment uncertainty is the use of probabilistic evolutionary models for joint estimation of phylogeny and alignment.
