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Management experts have long recognized a problem with this approach: the difficulty of estimating how much value a person adds.
However, the approach is underutilised in the bioprocess industry due to challenges including lack of accessible tools to support a structured approach, the difficulty of realising computationally tractable (low parameter) yet realistic models, and the specialised skill sets required.
There are other difficulties associated with this approach: the difficulty of quantifying each of the factors, particularly the psychosocial and the global risk; the physician's loss of autonomy in whether or not to accept a patient on the waiting list for transplantation; loss of the human aspects of the physician-patient relationship and of the total picture of the patient.
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Stephen Baker explains that Google has approached the difficulty of machine translation not by coming up with a "Hansard algorithm" but by essentially entering all of Hansard into the program, creating such a huge corpus of French/English sentences that it can almost always find a near-match for any sentence you give it and tap-dance its way around the rest.
With the transition of design method from traditional frequency domain approaches to more refined direct time domain approaches, the difficulty of time integration of these systems occurs sometimes.
Difficulties of Following a Diet One problem with a drug-free approach is the difficulty many patients have in adopting and sticking with a diet and exercise program that can significantly lower their pressure.
One of the limitations of the approach is the difficulty of accurately characterizing weak binding events.
One yet unsolved problem with this approach is the difficulty of imaging and segmenting the bones.
A problem with this approach is the difficulty in assessing the credibility of model simulation results.
However, a known limitation in this approach is the difficulty of systematically incorporating constraints.
The approach surmounted the difficulty of the large size difference between the chip and the ULK layers in computations.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com