This pharmcogenomics approach supposed that genes with patterns of expression across the cell lines which are highly correlated with compound sensitivity are candidate clinical biomarkers of drug efficacy, potentially even direct effectors of drug action, or targets for novel drug development with existing compound leads.
Compared with ROI-seed-based approaches [ 10, 16, 45 ], the presently applied seed-voxel approach is supposed to provide some advantages: first, spatial smoothing with sufficient kernel size improves highly correlated time courses of adjacent voxels [ 45 ] so that the location of the seed-voxel is assumed to be robust against displacements.
This get-tough approach was supposed to deter crime.
The austerity approach was supposed to reduce Greece's ratio of debt to gross domestic product.
This approach is supposed to speed us up, and it creates alignment every 30 days, and you're constantly giving feedback.
Although the approach is supposed to be applicable at the same time as the revised original methodology comes into force, perhaps in three years, there is much work to be done by then.
The new approach is supposed to take advantage of improved household surveys in poor countries, and presumably the F.A.O. will eventually supply updated estimates for hunger in 2009 and 2010.
In this way, many open-source projects look more hierarchical than the corporate organograms the approach is supposed to have torn up.Even if the cracks in the management of open source can be plugged by some fairly straightforward organisational controls, might it nevertheless remain only a niche activity occupying, essentially, the space between a corporation and a commune?
Conversely, an internalist approach is supposed to require discrimination between extensionally equivalent but intensionally distinct theories.
The Intercom approach is supposed to be integrated in three important ways.
