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However, we note that our approach still performs considerably well when as little as 20% of each trace is considered, thus suggesting a good robustness against the lack of available observations.
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Results using the interaction gain (Additional file 3) show that increasing the number of samples reduces false positive rate for both the direct approach and replication groups scoring, with the direct approach still performing consistently better.
Analytical method validation is then the natural demonstration that the developed methods are fit for their intended purpose and is not any more the inconsiderate checklist validation approach still generally performed to complete the filing required to obtain product marketing authorization.
Here, the modified hill-climbing approach showed a better sensitivity and specificity than the pure hill-climbing approach, but still performed much worse than our genetic algorithm (Table 4).
Despite the above, several challenges remain where the simple combinatorial approach of MetFrag and MAGMa still performs best.
Although it was demonstrated that the basic method developed here (Fig. 2a) was applicable for the isolation of yeast cells with mating ability from common sake yeast strains, due to the requirement for the repeated exchange of plasmids, this approach still required multiple steps to perform the final hybridization and isolated a- or α-type derivatives.
We will then discuss the more extensive redesign approach of an enzyme, glyoxolase II, structurally unrelated to CA and MMP but that still performs hydrolytic catalysis.
-- still performs here, too".
And, Mr. Tribuzio still performs.
He still performs in China.
Mr. D'Aleo still performs with the group.
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