It is shown that the nonsmooth approach offers potent and flexible alternatives in this difficult context.
In summary, we demonstrate that optical barcoding is a powerful technique for clonal cell tracking in vitro and in vivo, rendering this approach a potent tool for studying the heterogeneity of complex tissues, in particular, cancer.
Our gene therapy approach showed potent tumor suppressor activity for intracranial brain tumor with no toxic side effects.
Our experimental approach confirms potent efficacy of LIF-NP for myelin repair in mice in vivo.
Combining the individualised mutanome-vaccine approach with potent immunomodulatory therapies, such as anti-checkpoint inhibitor antibodies, will open additional avenues for further clinical development (Garber, 2013).
The side effects of anticancer agents are a serious problem in cancer chemotherapy and an effective anticancer approach with potent activity and minimal side effects is highly desirable [ 15].
This approach uses potent chemical mutagens, such as N-ethyl N-nitrosourea (ENU), to randomly induce mutations in mice, which are then bred and phenotypically screened to identify lines that disrupt a specific biological process of interest.
As a proof of principle for this approach, a potent antagonist of quorum sensing in the bacteria Chromobacterium violaceum was shown to protect C. elegans from bacterial killing (Swem et al., 2009).
One strategy is to apply chemical genetic approaches utilizing potent and selective PTP inhibitors to study the physiological roles of the PTPs in vivo.
Tissue engineering approaches are potent methods for cartilage repair.
