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In this approach, pool metabolites are dealt with by removing them from the network before analysis.
Taking such an approach, Pool and Aquadro (2007) obtained sequence polymorphism data at the ebony locus from populations sampled along an altitudinal cline for abdominal pigmentation and found evidence for a partial selective sweep spanning the upstream noncoding region of ebony.
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Using the frequentist approach, pooling the 4 risk estimates from these 4 studies yields a pooled risk ratio estimate of 1.06 (95% confidence interval = 1.00 1.13).
Therefore, the present study used a meta-analysis approach, pooling the appropriate data from published studies to investigate the association of GBA mutations and Parkinson's disease in a Chinese population.
The second approach pools data across individuals of the same species pair.
The third approach pools data from individuals with several diseases prior to the statistical analysis, and has been used in the original WTCCC study.
Secondly, we used a pragmatic approach, pooling participants with comparable migration motives and patterns (i.e. Italian, Spanish and Portuguese subjects).
This over-sequencing can be reasonably reduced using a multiplex approach, pooling either different amplicons generated from the same DNA [ 37, 38] or the same amplicons derived from multiple DNAs using a barcoding strategy [ 39].
While we find little direct evidence of selection at the level of individual SNPs, the identification of genomic islands of differentiation under an HMM approach pooling information over linked SNPs reveals more powerful.
This approach pools sets of overlapping CNVs, so that CNVs of slightly different lengths and positions can be compared as part of the same CNVR, and facilitates case control testing of specific CNV loci.
In a proof-of-concept approach, pooled RNA representing a single biological replicate of control and drought stressed leaves of the Musa cultivar 'Cachaco' were hybridised to the Affymetrix Rice Genome Array.
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