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This indirect approach of validation is also known as 'pattern oriented modelling' [30, 31], 'indirect' [29] or 'secondary predictions' [28].
This approach of validation had earlier been effective in 80% of the examples.
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Rather than verify the compiler, the approach of translation validation performs a validation check after every run of the compiler, producing a formal proof that the produced target code is a correct implementation of the source code.
There is an increasing need of a quantitative approach for validation of high fidelity simulations that is comprehensive, consistent, and effective.
One approach to validation of reports of infections is to compare parental/carer reports with medical records but this is compromised by differences in health seeking behaviours between individuals [ 48].
This work demonstrated a new approach for validation of carbon source utilization of ancestral models, yielding accuracies of >75%, for aerobic and anaerobic conditions for the ancestral core models for Ecoli/Shigella, E. coli/ Shigella/ Salmonella, and enterobacteria.
The standard PCR-based approach of SNP validation by designing primers flanking an SNP, sequencing amplicons, and comparing them with expected genotype is not strictly applicable for a heterozygous genome due to possible amplification artifacts.
This work demonstrated a new approach for validation of carbon source utilization, yielding accuracies of >88% for aerobic and anaerobic conditions for all six E. coli strains examined.
Regardless of the justification for any post hoc manipulation, the approach to validation of a model is the same, no matter how a PI was obtained.
This approach to validation of a measure is used in the absence of a gold standard (where one would be able to establish 'criterion validity') and refers to predictions based on hypotheses.
NMR is of particular importance for identifying weak binders for the fragment-based approach, for validation of high-throughput screening hits, and for structure-based design.
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