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Taking the approach of screening natural compounds for their ability to block common resistance mechanisms has great potential, especially since combination therapy may dramatically extend the life of new antibiotic drugs, thus making their development more economically attractive.
Finally our approach of screening the IgM+ memory repertoire could be applied to identify conserved and functionally relevant targets on other rapidly evolving pathogens.
The novel association of the oncogenic pathway activation status with a phenotype "captured" by a marker 19-gene profile, of which none of the pathway genes is a member, demonstrates that biological inference in microarray studies should not be limited to the frequently applied approach of screening a list of top marker genes in a prognostic signature.
In this study, rather than just analyse the previously reported SNPs, we took the approach of screening the whole gene using a tagging SNP approach.
However, even the approach of screening only high-risk women between 35 and 79 years of age may be appropriate if it is acceptable to the public and there is strong evidence of overall benefit.
Therefore, rather than saturate the transposon mutagenesis screen, which would require testing 30,000 transformants (Burns et al. 1994), we switched to the more systematic approach of screening the deletion set.
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Our approach consists of screening green algal nuclear genes for the presence of non-canonical glutamine codons and interpreting the evolution of the genetic code and glutamine codon usage in a phylogenetic framework.
Gwathmey, J. K., Tsaioun, K. & Hajjar, R. J. Cardionomics: a new integrative approach for screening cardiotoxicity of drug candidates.
Based on our study, we suggest an alternative approach of directly screening all ARDS patients with BCCE, which we believe can be done quickly at the bedside.
We have here adopted the same approach of extract screening to look for antigens that might form the basis of a serological test for T. b. rhodesiense infection, but have followed up with further tests using recombinant proteins.
Twenty four allocations were initially generated for each of the possible factorial combinations of screening approach, screening tool, and intervention.
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CEO of Professional Science Editing for Scientists @ prosciediting.com