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Reporter constructs containing candidate microRNA target sites are a popular approach of functional studies, and full-length 3′-UTR sequences are preferred because they contain all regulatory elements and preserve higher order structure as much as possible.
In this paper, three artificial intelligence techniques (AI) such as hybrid approach of functional link artificial neural network (FLANN) with genetic algorithm (GA), particle swarm optimization (PSO) and clonal selection algorithm (CSA), i.e., FLANN-Genetic (FGA and AFGA), FLANN-PSO (FPSO and MFPSO), FLANN-CSA (FCSA) are applied to design a model for predicting maintainability.
Recently, there has been a tremendous interest in 3D printing which is one of research branches in additive direct printing approach of functional materials.
This is the approach of functional medicine -- a complete rethinking of health and disease based on systems thinking, on understanding the body as a complex network, not a bunch of unrelated organs.
The aim of the CyberHand is to investigate methodologies that go beyond this straightforward approach of functional replacement and to ultimately connect the hand with the human brain.
For these reasons we directed our attention to development of an evolution-based molecular-genetic approach of functional analysis in fission yeast as a way to dissect the molecular basis of known and unknown functions of tropomyosin in a living cell.
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Indeed, we identified altered modules with functions similar to those described by other authors using different approaches of functional gene expression in HNSCC.
This problem prompted us to employ a bioinformatic tool for analysis of the N. crassa genome that does not rely on conventional approaches of functional annotation.
In contrast to the approaches of functional connectivity, models of effective connectivity facilitate description of the causality of interactions among brain regions.
Moreover, by smart organic synthesis, artificial DNA bases would enrich this field with innovative properties and can also give rise to novel choreographed approaches of functional DNA self-assembly.
The most straight-forward approach of miRNA functional annotation is through functional enrichment analysis using the miRNA-target genes.
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