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In the last couple of years a small group of fiction writers has taken the craftier approach of circulating plagiarism accusations against an acclaimed author by mass e-mail to members of the literary community.
Unlike Frankfurter, who aggressively lobbied for votes on cases, Burton honoured the more traditional approach of circulating drafts of opinions; and unlike Hugo Black, William O. Douglas, and Earl Warren, Burton was not an opinion leader.
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The purpose of this study was to investigate, using a previously described biomarker discovery approach, a subset of circulating proteins and their association with PTB focusing on samples from early pregnancy.
Cheung et al. (2012) pioneered a new immunoproteogenomics approach for identification of circulating monoclonal antibodies from serum that enables high-throughput antibody development.
Alternative approaches involving analysis of circulating biomarkers using gene expression (GE) show promise [ 2].
In particular, the development of a high-throughput approach for the detection of circulating claudin-4 will be crucial, as our current approach involving exosomes purification and detection by immunoblotting does not allow for large scale population testing and does not appears to provide improved sensitivity over the currently used CA125 marker.
A more objective approach is the quantification of circulating levels of lymphangiogenic growth factors, such as VEGF-C and VEGF-D, and of circulating lymphatic endothelial progenitor cells.
In the case of PSA-producing cells, plasma PSA may be used as an indicator of tumour burden, although this approach would lack validation of circulating PSA levels to actual tumour load (Thalmann et al, 1996).
This technique provides an efficient tool for the detection and quantification of these cells similar to the widely used approach for the detection of circulating tumor cells in the peripheral blood [ 21- 25].
The authors performed metabolomics approach to measure spectrum of circulating free fatty acid (FFA) from 452 individuals of normal weight (NW), metabolically health (MHO) and unhealthy obese subjects (MUO), further before and after weight loss intervention.
There are thus realistic positive perspectives for the treatment of human EE and MNGIE, especially considering the proof-of-principle, evidence-based demonstration that AAV-driven gene therapy is an effective and feasible approach for the treatment of circulating toxic compounds disorders and which is directly translatable to clinical practice.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com