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Second, the current approach of averaging oligonucleotide signals in a gene-oriented way impairs the resolution of splice isoforms or alternative transcripts.
We took the approach of averaging the predictions from the top univariate OLR models, to reduce the chance of serious over-fitting (average univariate prediction; AP).
Because of the small number of viral genes (18) a symmetrical approach of averaging over viral gene ranks was not performed.
Akin to neurologic scoring systems for DSP in which right-to-left averages are taken (5), we chose the approach of averaging the results of two images taken from contralateral eyes.
To overcome the major disadvantage of the small region of sampling in local sensitivity analysis while retaining the ease of computational simplicity, some studies have used a global approach of averaging local sensitivities taken throughout the parameter space [ 13].
On the one hand, the admittedly simple approach of averaging over genetic and environmental backgrounds and testing each marker in a GWAS for association with the studied trait marginally has proven quite successful, despite early concerns that by ignoring the underlying complexity this naïve approach would fail.
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Surprisingly, the approach of average AFs has only rarely been applied.
The same approach of average rank can be seen, for example, in [ 48] and it is used to rank objects based on several criteria simultaneously.
However as the adaptive evolution could affect only few sites at several time points, both approaches of averaging rates over sites or over time (over branches) could fail to detect positive selection.
However, since these approaches compare measures of averaged expression levels, they cannot study how the variance of expression levels across the genes/proteins of a cellular pathway (termed 'pathway expression variance' here) changes under different biological conditions.
The second approach is a continuous valve-like approach that allows investigation of averaged effects and large scale interaction and feedback effects.
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