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This approach of attaching a therapeutic to a bisphosphonate for bone targeting has previously proven successful in a mouse model of metastatic breast cancer [ 26].
This is contrary to human intuition because the opposite approach, of attaching a mechanism to a described adverse event, provides a good opportunity for avoiding or ameliorating the event, and accordingly we instinctively give mechanistic explanations quite a lot or even excessive weight.
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This approach of reversibly attaching probes to serum albumin may serve as a tool to optimize tracer distribution for more precise target characterization in molecular imaging experiments.
For a particle in planar motion, one approach to attaching physical significance to these terms is based on the concept of an instantaneous co-rotating frame of reference.
FBGA package reliability is usually assessed through the conventional approaches of die attach and mold compound material optimization.
In contrast, an alternative approach for obtaining the number of attached cross-bridges based on the maximum tension response to very rapid stretches [ 206] suggests lack of such proportionality [ 85].
In this study, we further develop this synthetic approach by attaching short peptide sequences to the Ir octaethylporphyrin (Ir OEP) via histidine residues (structural analogues of imidazoles).
Thus, we sought to combine principles from each of these approaches by attaching potent transcriptional activation domains to a natural reprogramming factor to increase the efficiency and/or rate of cell fate conversion.
Now women take more novel approaches, even attaching brooches to the back of a dress.
A detailed description of the approach is attached in the Appendix.
Angle of attach (rad, deg).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com